SrasV1, Main, Exploration, bibRecord, 000A29

A new coronavirus associated with human respiratory disease in China.

Identifieur interne : 000A29 ( Main/Exploration ); précédent : 000A28; suivant : 000A30

A new coronavirus associated with human respiratory disease in China.

Source :

Nature [ 1476-4687 ] ; 2020.

RBID : pubmed:32015508

Descripteurs français

KwdFr :
- ARN viral (génétique), Adulte, Chine, Génome viral (génétique), Humains, Infections à coronavirus (), Infections à coronavirus (anatomopathologie), Infections à coronavirus (imagerie diagnostique), Infections à coronavirus (virologie), Maladies transmissibles émergentes (), Maladies transmissibles émergentes (anatomopathologie), Maladies transmissibles émergentes (imagerie diagnostique), Maladies transmissibles émergentes (virologie), Mâle, Phylogénie, Pneumopathie virale (), Pneumopathie virale (anatomopathologie), Pneumopathie virale (imagerie diagnostique), Pneumopathie virale (virologie), Poumon (imagerie diagnostique), Recombinaison génétique (génétique), Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (imagerie diagnostique), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (étiologie), Tomodensitométrie.
MESH :
- anatomopathologie : Infections à coronavirus, Maladies transmissibles émergentes, Pneumopathie virale, Syndrome respiratoire aigu sévère.
- génétique : ARN viral, Génome viral, Recombinaison génétique.
- imagerie diagnostique : Infections à coronavirus, Maladies transmissibles émergentes, Pneumopathie virale, Poumon, Syndrome respiratoire aigu sévère.
- virologie : Infections à coronavirus, Maladies transmissibles émergentes, Pneumopathie virale, Syndrome respiratoire aigu sévère.
- étiologie : Syndrome respiratoire aigu sévère.
- Adulte, Chine, Humains, Infections à coronavirus, Maladies transmissibles émergentes, Mâle, Phylogénie, Pneumopathie virale, Tomodensitométrie.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Adult, Betacoronavirus (classification), Betacoronavirus (genetics), China, Communicable Diseases, Emerging (complications), Communicable Diseases, Emerging (diagnostic imaging), Communicable Diseases, Emerging (pathology), Communicable Diseases, Emerging (virology), Coronavirus Infections (complications), Coronavirus Infections (diagnostic imaging), Coronavirus Infections (pathology), Coronavirus Infections (virology), Genome, Viral (genetics), Humans, Lung (diagnostic imaging), Male, Phylogeny, Pneumonia, Viral (complications), Pneumonia, Viral (diagnostic imaging), Pneumonia, Viral (pathology), Pneumonia, Viral (virology), RNA, Viral (genetics), Recombination, Genetic (genetics), Severe Acute Respiratory Syndrome (diagnostic imaging), Severe Acute Respiratory Syndrome (etiology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Tomography, X-Ray Computed, Whole Genome Sequencing.
MESH :
- chemical , genetics : RNA, Viral.
- geographic : China.
- classification : Betacoronavirus.
- complications : Communicable Diseases, Emerging, Coronavirus Infections, Pneumonia, Viral.
- diagnostic imaging : Communicable Diseases, Emerging, Coronavirus Infections, Lung, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- etiology : Severe Acute Respiratory Syndrome.
- genetics : Betacoronavirus, Genome, Viral, Recombination, Genetic.
- pathology : Communicable Diseases, Emerging, Coronavirus Infections, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- virology : Communicable Diseases, Emerging, Coronavirus Infections, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- Adult, Humans, Male, Phylogeny, Tomography, X-Ray Computed, Whole Genome Sequencing.

Abstract

Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health^1-3. Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing⁴ of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here 'WH-Human 1' coronavirus (and has also been referred to as '2019-nCoV'). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China⁵. This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans.

DOI: 10.1038/s41586-020-2008-3
PubMed: 32015508

Affiliations:

Le document en format XML

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<author><name sortKey="Yu, Bin" sort="Yu, Bin" uniqKey="Yu B" first="Bin" last="Yu">Bin Yu</name>
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<author><name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name>
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<wicri:regionArea>Department of Zoonosis, National Institute for Communicable Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing</wicri:regionArea>
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<author><name sortKey="Song, Zhi Gang" sort="Song, Zhi Gang" uniqKey="Song Z" first="Zhi-Gang" last="Song">Zhi-Gang Song</name>
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<author><name sortKey="Tao, Zhao Wu" sort="Tao, Zhao Wu" uniqKey="Tao Z" first="Zhao-Wu" last="Tao">Zhao-Wu Tao</name>
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<author><name sortKey="Tian, Jun Hua" sort="Tian, Jun Hua" uniqKey="Tian J" first="Jun-Hua" last="Tian">Jun-Hua Tian</name>
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<author><name sortKey="Pei, Yuan Yuan" sort="Pei, Yuan Yuan" uniqKey="Pei Y" first="Yuan-Yuan" last="Pei">Yuan-Yuan Pei</name>
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<author><name sortKey="Yuan, Ming Li" sort="Yuan, Ming Li" uniqKey="Yuan M" first="Ming-Li" last="Yuan">Ming-Li Yuan</name>
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<author><name sortKey="Zhang, Yu Ling" sort="Zhang, Yu Ling" uniqKey="Zhang Y" first="Yu-Ling" last="Zhang">Yu-Ling Zhang</name>
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<author><name sortKey="Dai, Fa Hui" sort="Dai, Fa Hui" uniqKey="Dai F" first="Fa-Hui" last="Dai">Fa-Hui Dai</name>
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<author><name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name>
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<wicri:regionArea>Shanghai Public Health Clinical Center, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Qi Min" sort="Wang, Qi Min" uniqKey="Wang Q" first="Qi-Min" last="Wang">Qi-Min Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Public Health Clinical Center, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Jiao Jiao" sort="Zheng, Jiao Jiao" uniqKey="Zheng J" first="Jiao-Jiao" last="Zheng">Jiao-Jiao Zheng</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Public Health Clinical Center, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Xu, Lin" sort="Xu, Lin" uniqKey="Xu L" first="Lin" last="Xu">Lin Xu</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Public Health Clinical Center, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Public Health Clinical Center, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Yong Zhen" sort="Zhang, Yong Zhen" uniqKey="Zhang Y" first="Yong-Zhen" last="Zhang">Yong-Zhen Zhang</name>
<affiliation wicri:level="1"><nlm:affiliation>Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. zhangyongzhen@shphc.org.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Shanghai Public Health Clinical Center, Fudan University, Shanghai</wicri:regionArea>
<wicri:noRegion>Shanghai</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature</title>
<idno type="eISSN">1476-4687</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Betacoronavirus (classification)</term>
<term>Betacoronavirus (genetics)</term>
<term>China</term>
<term>Communicable Diseases, Emerging (complications)</term>
<term>Communicable Diseases, Emerging (diagnostic imaging)</term>
<term>Communicable Diseases, Emerging (pathology)</term>
<term>Communicable Diseases, Emerging (virology)</term>
<term>Coronavirus Infections (complications)</term>
<term>Coronavirus Infections (diagnostic imaging)</term>
<term>Coronavirus Infections (pathology)</term>
<term>Coronavirus Infections (virology)</term>
<term>Genome, Viral (genetics)</term>
<term>Humans</term>
<term>Lung (diagnostic imaging)</term>
<term>Male</term>
<term>Phylogeny</term>
<term>Pneumonia, Viral (complications)</term>
<term>Pneumonia, Viral (diagnostic imaging)</term>
<term>Pneumonia, Viral (pathology)</term>
<term>Pneumonia, Viral (virology)</term>
<term>RNA, Viral (genetics)</term>
<term>Recombination, Genetic (genetics)</term>
<term>Severe Acute Respiratory Syndrome (diagnostic imaging)</term>
<term>Severe Acute Respiratory Syndrome (etiology)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Tomography, X-Ray Computed</term>
<term>Whole Genome Sequencing</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>Adulte</term>
<term>Chine</term>
<term>Génome viral (génétique)</term>
<term>Humains</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (anatomopathologie)</term>
<term>Infections à coronavirus (imagerie diagnostique)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Maladies transmissibles émergentes ()</term>
<term>Maladies transmissibles émergentes (anatomopathologie)</term>
<term>Maladies transmissibles émergentes (imagerie diagnostique)</term>
<term>Maladies transmissibles émergentes (virologie)</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Pneumopathie virale ()</term>
<term>Pneumopathie virale (anatomopathologie)</term>
<term>Pneumopathie virale (imagerie diagnostique)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Poumon (imagerie diagnostique)</term>
<term>Recombinaison génétique (génétique)</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (imagerie diagnostique)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Syndrome respiratoire aigu sévère (étiologie)</term>
<term>Tomodensitométrie</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
<term>Pneumopathie virale</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Coronavirus Infections</term>
<term>Lung</term>
<term>Pneumonia, Viral</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Betacoronavirus</term>
<term>Genome, Viral</term>
<term>Recombination, Genetic</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
<term>Génome viral</term>
<term>Recombinaison génétique</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
<term>Pneumopathie virale</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
<term>Pneumopathie virale</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Communicable Diseases, Emerging</term>
<term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Humans</term>
<term>Male</term>
<term>Phylogeny</term>
<term>Tomography, X-Ray Computed</term>
<term>Whole Genome Sequencing</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Chine</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Maladies transmissibles émergentes</term>
<term>Mâle</term>
<term>Phylogénie</term>
<term>Pneumopathie virale</term>
<term>Tomodensitométrie</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health<sup>1-3</sup>
. Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing<sup>4</sup>
 of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here 'WH-Human 1' coronavirus (and has also been referred to as '2019-nCoV'). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China<sup>5</sup>
. This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Hubei</li>
</region>
<settlement><li>Pékin</li>
<li>Wuhan</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Fan" sort="Wu, Fan" uniqKey="Wu F" first="Fan" last="Wu">Fan Wu</name>
</noRegion>
<name sortKey="Chen, Yan Mei" sort="Chen, Yan Mei" uniqKey="Chen Y" first="Yan-Mei" last="Chen">Yan-Mei Chen</name>
<name sortKey="Dai, Fa Hui" sort="Dai, Fa Hui" uniqKey="Dai F" first="Fa-Hui" last="Dai">Fa-Hui Dai</name>
<name sortKey="Holmes, Edward C" sort="Holmes, Edward C" uniqKey="Holmes E" first="Edward C" last="Holmes">Edward C. Holmes</name>
<name sortKey="Hu, Yi" sort="Hu, Yi" uniqKey="Hu Y" first="Yi" last="Hu">Yi Hu</name>
<name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name>
<name sortKey="Pei, Yuan Yuan" sort="Pei, Yuan Yuan" uniqKey="Pei Y" first="Yuan-Yuan" last="Pei">Yuan-Yuan Pei</name>
<name sortKey="Song, Zhi Gang" sort="Song, Zhi Gang" uniqKey="Song Z" first="Zhi-Gang" last="Song">Zhi-Gang Song</name>
<name sortKey="Tao, Zhao Wu" sort="Tao, Zhao Wu" uniqKey="Tao Z" first="Zhao-Wu" last="Tao">Zhao-Wu Tao</name>
<name sortKey="Tian, Jun Hua" sort="Tian, Jun Hua" uniqKey="Tian J" first="Jun-Hua" last="Tian">Jun-Hua Tian</name>
<name sortKey="Wang, Qi Min" sort="Wang, Qi Min" uniqKey="Wang Q" first="Qi-Min" last="Wang">Qi-Min Wang</name>
<name sortKey="Wang, Wen" sort="Wang, Wen" uniqKey="Wang W" first="Wen" last="Wang">Wen Wang</name>
<name sortKey="Xu, Lin" sort="Xu, Lin" uniqKey="Xu L" first="Lin" last="Xu">Lin Xu</name>
<name sortKey="Yu, Bin" sort="Yu, Bin" uniqKey="Yu B" first="Bin" last="Yu">Bin Yu</name>
<name sortKey="Yuan, Ming Li" sort="Yuan, Ming Li" uniqKey="Yuan M" first="Ming-Li" last="Yuan">Ming-Li Yuan</name>
<name sortKey="Zhang, Yong Zhen" sort="Zhang, Yong Zhen" uniqKey="Zhang Y" first="Yong-Zhen" last="Zhang">Yong-Zhen Zhang</name>
<name sortKey="Zhang, Yu Ling" sort="Zhang, Yu Ling" uniqKey="Zhang Y" first="Yu-Ling" last="Zhang">Yu-Ling Zhang</name>
<name sortKey="Zhao, Su" sort="Zhao, Su" uniqKey="Zhao S" first="Su" last="Zhao">Su Zhao</name>
<name sortKey="Zheng, Jiao Jiao" sort="Zheng, Jiao Jiao" uniqKey="Zheng J" first="Jiao-Jiao" last="Zheng">Jiao-Jiao Zheng</name>
</country>
</tree>
</affiliations>
</record>

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A new coronavirus associated with human respiratory disease in China.

A new coronavirus associated with human respiratory disease in China.

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